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Background

MicroVue YKL-40 (hcGP39, CHI3L1) is a 40 kDA heparin-binding glycoprotein first described by…

The biological function of YKL-40 is unknown but it has been shown to be a potent growth factor and a potent migration factor for endothelial cells. While YKL-40 is not significantly expressed in normal tissues, several studies have demonstrated substantial levels of YKL-40 expression in environments with inflammation or where substantial remodeling of the extracellular matrix (ECM) occurs (e.g. cancer, rheumatoid arthritis and fibrosis).

  • YKL-40 is expressed by several types of primary and secondary carcinoma (breast, colon, lung, kidney, ovarian, prostate, uterine, oligodendroglioma, glioblastoma, osteosarcoma and germ cell tumors) (Johansen et al. 1992; Morrison et al. 1994; and the NCBI data base).
  • YKL-40 is expressed by several types of carcinoma (breast, colon, lung, kidney, ovarian, prostate, uterine, oligodendroglioma, glioblastoma, osteosarcoma and germ cell tumors) (Johansen et al. 1992; Morrison et al. 1994; and the NCBI data base). YKL-40 is also secreted by macrophages (Kirckpatrick et al. 1997; Rehli et al. 1997; Boot et al. 1999; Johansen et al. 1999; Baeten et al. 2000), neutrophils (Volck et al. 1998) and chondrocytes (Hakala et al. 1993; Johansen et al. 2001).